Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG 		0.400 Biomarker disease BEFREE ⁵¹Cr release assay, CD107a assay, and IFN-γ secretion assay were performed to detect the sensitivity of lung cancer cell lines A549 and H1975 to NK cells cytotoxicity in the presence of gefitinib. 23937717 2013
Entrez Id: 23583
Gene Symbol: SMUG1
SMUG1 		0.100 Biomarker disease BEFREE • Bone marrow FDG uptake can provide information on predicting lung cancer progression. 27590191 2017
Entrez Id: 114757
Gene Symbol: CYGB
CYGB 		0.030 Biomarker disease BEFREE ΔNp63 targets cytoglobin to inhibit oxidative stress-induced apoptosis in keratinocytes and lung cancer. 26096935 2016
Entrez Id: 3014
Gene Symbol: H2AX
H2AX 		0.070 AlteredExpression disease BEFREE γ-H2AX activity as shown by measuring DSB damage in ionizing radiation-irradiated PBLs may be a novel phenotypic marker of lung cancer risk. 23300022 2013
Entrez Id: 2146
Gene Symbol: EZH2
EZH2 		0.100 Biomarker disease BEFREE β-Elemene Synergizes With Gefitinib to Inhibit Stem-Like Phenotypes and Progression of Lung Cancer via Down-Regulating EZH2. 30555330 2018
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 AlteredExpression disease BEFREE β-Elemene against human lung cancer via up-regulation of P53 protein expression to promote the release of exosome. 25204604 2014
Entrez Id: 1137
Gene Symbol: CHRNA4
CHRNA4 		0.100 Biomarker disease BEFREE α7-nAChR silencing inhibits lung cancer proliferation. 25324001 2014
Entrez Id: 407041
Gene Symbol: MIR34B
MIR34B 		0.360 Biomarker disease CTD_human α4 is highly expressed in carcinogen-transformed human cells and primary human cancers. 21339737 2011
Entrez Id: 3476
Gene Symbol: IGBP1
IGBP1 		0.300 Biomarker disease CTD_human α4 is highly expressed in carcinogen-transformed human cells and primary human cancers. 21339737 2011
Entrez Id: 100
Gene Symbol: ADA
ADA 		0.330 Biomarker disease CTD_human [Increase of the functional activity of natural killers under the effects of the pharmacological correction of the sympathoadrenal system state in patients with lung cancer]. 2305558 1990
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 Therapeutic disease CTD_human [Experimental study on combination of Ad-p53 with CDDP or As(2)O(3) in human lung adenocarcinoma cell line GLC-82]. 11798837 2000
Entrez Id: 7157
Gene Symbol: TP53
TP53 		0.800 Biomarker disease CTD_human [Experimental study on combination of Ad-p53 with CDDP or As(2)O(3) in human lung adenocarcinoma cell line GLC-82]. 11798837 2000
Entrez Id: 4233
Gene Symbol: MET
MET 		0.400 Biomarker disease BEFREE [Corrigendum] AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis. 30542697 2019
Entrez Id: 558
Gene Symbol: AXL
AXL 		0.100 Biomarker disease BEFREE [Corrigendum] AXL and MET receptor tyrosine kinases are essential for lung cancer metastasis. 30542697 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS 		0.700 Biomarker disease CTD_human [K-ras gene mutations of asbestos and welding-fumes related human lung cancer]. 12725029 2000
Entrez Id: 7545
Gene Symbol: ZIC1
ZIC1 		0.010 AlteredExpression disease BEFREE ZIC1 knockdown inhibits proliferation, reduces invasion, and induces apoptosis in dedifferentiated and myxoid/round cell liposarcoma cell lines, but not in either adipose-derived stem cells or in a lung cancer cell line with low ZIC1 expression. 20713527 2010
Entrez Id: 4017
Gene Symbol: LOXL2
LOXL2 		0.020 Biomarker disease BEFREE ZEB1 induces LOXL2-mediated collagen stabilization and deposition in the extracellular matrix to drive lung cancer invasion and metastasis. 27694892 2017
Entrez Id: 5599
Gene Symbol: MAPK8
MAPK8 		0.100 Biomarker disease BEFREE ZCCHC9 promotes proliferation and invasion of lung cancer through regulating the JNK pathway. 30644129 2019
Entrez Id: 5226
Gene Symbol: PGD
PGD 		0.020 AlteredExpression disease BEFREE YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. 31504235 2019
Entrez Id: 406924
Gene Symbol: MIR134
MIR134 		0.030 Biomarker disease BEFREE YKT6 is a key molecule in the regulation of exosome release in lung cancer cells and is in turn precisely regulated by miR-134 and miR-135b. 27285987 2016
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2 		0.100 Biomarker disease BEFREE YHO-13177 potentiated the cytotoxicity of SN-38, mitoxantrone, and topotecan in both BCRP-transduced human colon cancer HCT116 (HCT116/BCRP) cells and SN-38-resistant human lung cancer A549 (A549/SN4) cells that express BCRP, but had little effect in the parental cells. 21566063 2011
Entrez Id: 1548
Gene Symbol: CYP2A6
CYP2A6 		0.400 Biomarker disease BEFREE Yet only in Asian populations, both Japanese and Chinese, which have a high prevalence of genetic variants, has a link between CYP2A6, smoking dose, and lung cancer been established. 28092945 2017
Entrez Id: 494324
Gene Symbol: MIR375
MIR375 		0.040 Biomarker disease BEFREE YAP1 showed a negative correlation with miR-375 in a panel of lung cancer cell lines and growth inhibitory activities in NE-lung cancer cells. 21856745 2011
Entrez Id: 5591
Gene Symbol: PRKDC
PRKDC 		0.030 GeneticVariation disease BEFREE XRCC6 and XRCC7 with susceptibility and survival in North Indian lung cancer patients. 29397516 2018
Entrez Id: 5595
Gene Symbol: MAPK3
MAPK3 		0.400 Biomarker disease BEFREE XRCC1 is an important scaffold protein involved in base excision repair that is regulated by ERK1/2 and AKT signals and plays an important role in the development of lung cancer. 26046675 2015